MTSU vs. Sam Houston Football Prediction & Odds - Nov. 22

The Middle Tennessee Blue Raiders (1-9) and the Sam Houston Bearkats (2-8) play on Saturday, November 22, 2025 at Johnny "Red" Floyd Stadium in a battle of CUSA opponents.

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Middle Tennessee vs. Sam Houston Matchup Info

  • Game date: Saturday, November 22, 2025
  • Game time: 3 p.m. ET
  • Location: Murfreesboro, Tennessee
  • Venue: Johnny "Red" Floyd Stadium
  • TV channel: ESPN+
  • Live Stream: Watch this game on ESPN+

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Middle Tennessee vs. Sam Houston Odds and Prediction

  • Spread favorite: Blue Raiders (-6.5)
  • Moneyline: Blue Raiders (-251), Bearkats (+204)
  • Total: 53.5 points
  • Pick ATS: Sam Houston (+6.5)
  • Pick OU: Over (53.5)
  • Prediction: Middle Tennessee 29, Sam Houston 25

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Middle Tennessee vs. Sam Houston Betting Records and Insights

  • Middle Tennessee has put together a 4-6-0 record against the spread this season.
  • Sam Houston has put together a 3-7-0 ATS record so far this year.
  • The Blue Raiders have not covered the spread when favored by 6.5 points or more this season (in one opportunity).
  • The Bearkats have been an underdog by 6.5 points or more eight times this year, and covered the spread in three of those games.
  • So far this season, five of Middle Tennessee's 10 games have hit the over.
  • Sam Houston and its opponent have combined to go over the point total six out of 10 times this year.

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