Houston vs. TCU Football Prediction & Odds - Nov. 22

West Virginia v Houston

Photo: Maria Lysaker / Getty Images Sport / Getty Images

The No. 25 Houston Cougars (8-2) host a Big 12 showdown against the TCU Horned Frogs (6-4) on Saturday, November 22, 2025 at TDECU Stadium.

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Houston vs. TCU Matchup Info

  • Game date: Saturday, November 22, 2025
  • Game time: 4 p.m. ET
  • Location: Houston, Texas
  • Venue: TDECU Stadium
  • TV channel: FOX
  • Live Stream: Watch this game on Fubo (Regional restrictions may apply)

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Houston vs. TCU Odds and Prediction

  • Spread favorite: Cougars (-1.5)
  • Moneyline: Cougars (-115), Horned Frogs (-104)
  • Total: 55 points
  • Pick ATS: Houston (-1.5)
  • Pick OU: Over (55)
  • Prediction: Houston 30, TCU 26

Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.

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Houston vs. TCU Betting Records and Insights

  • Houston has won seven games against the spread this season, while failing to cover three times.
  • TCU has won four games against the spread this season, failing to cover or pushing six times.
  • The Cougars are 5-2 ATS this season when playing as at least 1.5-point favorites.
  • The Horned Frogs have not covered the spread when an underdog by 1.5 points or more this year (in two opportunities).
  • A total of seven out of 10 Houston games this season have hit the over.
  • In TCU's 10 contests this season, the combined scoring has gone over the point total five times.

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