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Mavericks vs. Spurs Predictions, Odds & Stats – Oct. 22

San Antonio Spurs v Indiana Pacers

Photo: Justin Casterline / Getty Images Sport / Getty Images

In the 2025-26 season opener for both teams, the Dallas Mavericks are favored by 2.5 points against the San Antonio Spurs on Wednesday, October 22, 2025 at 9:30 p.m. ET. The matchup airs on ESPN.

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Listen to the game on 97.1 The Eagle

Mavericks vs. Spurs Predictions for Wednesday

Our computer projection model for this contest expects a final tally of Mavericks 118, Spurs 112.

  • Moneyline Pick: Mavericks (-149)
  • Total Pick: Over 223.5 (computer predicts 230.1 points)
  • Pick ATS: Mavericks (-2.5)

Recent Mavericks vs. Spurs Matchups

Mavericks vs Spurs (Recent Matchups)
Date Favorite Spread Total Favorite Moneyline Underdog Moneyline Result
3/12/2025 Spurs -6.5 236.5 -239 +195 126-116 SA
3/10/2025 Spurs -6.5 234 -267 +216 133-129 DAL
11/16/2024 Mavericks -13.5 229 -901 +602 110-93 DAL
10/24/2024 Mavericks -8.5 227.5 -389 +303 120-109 DAL

Mavericks 2024-25 Betting Trends

  • Against the spread, Dallas was 39-42-1 last year.
  • Against the spread, as 2.5-point favorites or more, the Mavericks went 16-15 last season.
  • Of Dallas' 82 games last year, 46 hit the over.
  • The Mavericks won 63.9% of the games last season in which they were favored on the moneyline (23-13).
  • Dallas had a record of 21-9 in games it played as a moneyline favorite with odds of -149 or shorter last year (70%).

Spurs 2024-25 Betting Trends

  • San Antonio covered 39 times in 82 matchups with a spread last season.
  • The Spurs' ATS record as underdogs of 2.5 points or more was 24-29 last season.
  • San Antonio's games went over the point total 46 out of 82 times last season.
  • Last season, the Spurs won 16 out of the 57 games, or 28.1%, in which they were the underdog.
  • San Antonio had a record of 10-32, a 23.8% win rate, when it was set as the underdog by +126 or more by bookmakers last season.

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Mavericks vs. Spurs Injury Report

Mavericks

Mavericks:

Daniel Gafford: Day-To-Day (Ankle),

Dante Exum: Out (Knee),

Kyrie Irving: Out (Knee)

Spurs

Spurs:

Lindy Waters III: Out (Eye),

De'Aaron Fox: Out (Hamstring),

Kelly Olynyk: Out (Heel),

Jeremy Sochan: Out (Wrist)

Mavericks vs. Spurs Game Time and TV Channel

  • Game day: Wednesday, October 22, 2025
  • Game time: 9:30 p.m. ET
  • TV channel: ESPN
  • Location: Dallas, Texas
  • Arena: American Airlines Center
  • Live stream: Watch this game on Fubo (Regional restrictions may apply)

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